Basal Cell Carcinoma vs Seborrheic Keratosis

Basal cell carcinoma is the most common cancer in people. It grows slowly and very rarely spreads to other organs, but it does not heal on its own, and left alone it keeps growing into the skin and tissue around it. A seborrheic keratosis is a common, harmless growth that looks stuck onto the skin, like a piece of wax or a small barnacle. They are not cancer and they do not become cancer. The reason to see a doctor is to be sure that is what you are looking at.

Reviewed by Dr. Schwarz, Board-Certified Dermatologist · Research updated 2026-10-23
Existing educational image of Basal Cell CarcinomaTwo growths on the upper back on fair skin. One is a flat light tan patch and the other is a raised mid-brown growth with a rough waxy surface and a sharply defined edge.

Key differences

The same eight facts on every condition comparison.

Usual age
Over 40
40 and over
Where
Head and neck; trunk
Back, chest, face
Main sign
Pearly bump or sore that won't heal
Waxy stuck-on growth
Itch or pain
Usually none
Sometimes itchy
Contagious
No
No
Long term
Grows slowly; needs removal
Stays; more appear
Scars
Treatment leaves a scar
No
Who gets it
Fair, sun-exposed skin
Most people over 50

What is it?

Basal Cell Carcinoma
Seborrheic Keratosis
What is it?

It is a common skin cancer.
It usually grows locally and can damage surrounding tissue.

It looks different in different people.
It may be a pearly bump, scaly patch or sore that bleeds and heals.

It rarely spreads.
Distant spread is rare, but it still needs treatment.

Biopsy guides treatment.
Location, size, subtype and history shape the treatment plan.

It is a benign growth.
Surface skin cells form a waxy, warty or stuck-on growth.

Color varies.
It can be tan, brown, gray or almost black.

It is not a precancer.
These growths become more common with age.

Uncertain lesions are tested.
Tissue is examined before any destructive treatment if the appearance is unclear.

What it looks like

Basal Cell Carcinoma

Representative image of pearly skin nodule. This is a general visible-feature example, not an exact depiction of every subtype, stage or location, or a diagnostic reference.

Nodular basal cell carcinoma Pearly bump; most common.

Representative image of scaly pink patch. This is a general visible-feature example, not an exact depiction of every subtype, stage or location, or a diagnostic reference.

Superficial basal cell carcinoma Flat, scaly pink patch, often on the trunk.

A shiny pigmented dome-shaped nodule, representing pigmented basal cell carcinoma.

Pigmented basal cell carcinoma Brown to black pearly bump.

Representative image of scar like skin patch. This is a general visible-feature example, not an exact depiction of every subtype, stage or location, or a diagnostic reference.

Morpheaform basal cell carcinoma Scar-like and harder to see.

Seborrheic Keratosis

Close view of a rough hyperkeratotic brown stuck-on lesion, representing seborrheic keratosis.

Classic seborrheic keratosis Raised, waxy, stuck-on growth.

Multiple small gray-white raised bumps on the lower legs, representing stucco keratoses.

Stucco keratosis Small white-gray bumps on the legs.

Small dark raised papules on brown cheek skin, representing dermatosis papulosa nigra.

Dermatosis papulosa nigra Small dark bumps on the face.

Skin tones
Existing educational image of Basal Cell Carcinoma
Existing educational image of Basal Cell Carcinoma
Existing educational image of Basal Cell Carcinoma
Existing educational image of Basal Cell Carcinoma
Two growths on the upper back on fair skin. One is a flat light tan patch and the other is a raised mid-brown growth with a rough waxy surface and a sharply defined edge.
A raised brown growth on the chest on medium olive skin. Its color is only slightly deeper than the surrounding skin, but the rough waxy surface and the sharply drawn edge are clearly visible.
Several small, dark brown to black raised growths scattered over the cheek and temple on brown skin, ranging from one to three millimetres across, on otherwise even-toned skin.
A cluster of black raised growths along the side of the neck on deep brown skin, each with a sharply defined edge, with two flat darker marks nearby where earlier growths were treated.
Diagram
Basal Cell Carcinoma mechanism diagram. Cell-control signals change: DNA changes allow abnormal growth. Tumor nests grow into nearby skin: The cancer can extend below the surface. The surface may break down: A spot can bleed or fail to heal.
Seborrheic Keratosis mechanism diagram. A stuck-on plaque appears: The surface can look waxy or rough. Keratin collects in the growth: Tiny keratin-filled spaces may form. Surface cells grow locally: A benign epidermal growth develops.
In the skin

DNA changes disrupt normal growth signals in basal-type skin cells. Abnormal cell clusters can grow into nearby skin and produce a spot that bleeds, breaks down or fails to heal.

A benign overgrowth of surface skin cells creates a localized plaque. Keratin and sometimes pigment collect in the growth, giving it a waxy, rough or stuck-on appearance.

Where it shows up

Often on sun-exposed skin
Variable sites, often trunk or face

When it usually starts

010203040506070+

Basal Cell Carcinoma. Most common in adults with cumulative ultraviolet damage, though younger adults can develop it.

Seborrheic Keratosis. Usually appears in adult life and becomes increasingly common with age.

Causes and triggers

Causes

Basal cell carcinoma starts when ultraviolet light damages basal cells in the lowest layer of the epidermis.

Seborrheic keratoses are harmless growths of skin cells that become more common with age.

Family tendency

Fair skin, and rare conditions like Gorlin syndrome, raise the risk.

They often run in families.

Risk factors
Fair skin, Age over 50, Past radiation treatment, Weakened immunity
Age over 50, Family history, Sun exposure
Trigger
● Basal Cell Carcinoma
● Seborrheic Keratosis
Unprotected sun exposure
Well established
Not listed
Childhood sunburns
Strong link
Not listed
Tanning beds
Well established
Not listed
Aging
Not listed
Well established
Sun exposure
Not listed
Possible

Daily Care

Basal Cell Carcinoma
Seborrheic Keratosis
Daily care

Habits that help

  • Daily broad-spectrum sunscreen
    With clothing, hats and shade, fewer future tumors.
  • No tanning beds
    No version of this is safe.
  • Mohs surgery for high-risk tumors
    Edges checked before closing.
  • Curettage and electrodessication
    For small superficial tumors on trunk or limbs.
  • Prescription creams
    Imiquimod and 5-fluorouracil, for thin superficial tumors only.
  • Radiation treatment
    An option when surgery is not suitable.
  • Specialist drug treatment
    For rare advanced tumors.
  • Treating the sun damage around the tumor
    Rough scaly spots nearby are treated too.
  • Arrange early assessment for lesions on the nose, eyelids, ears or lips
    The nose, eyelids, ears and lips are time-sensitive.
  • Follow the specialist plan for a high-risk tumor subtype
    Infiltrative or morpheaform spreads further than it looks.
  • Discuss immune suppression and the need for closer monitoring
    More tumors, closer monitoring.

Avoid

  • Avoid: Reading the heal-and-return cycle as healing
    It is the classic sign.
  • Avoid: Continuing sun exposure and tanning beds
    More damage, more tumors.
  • Avoid: Picking or knocking the lesion
    Keeps the surface broken and hard to assess.
  • Avoid: Ignoring numbness or tingling
    The tumor may be tracking along a nerve.
  • Avoid: Waiting because it does not hurt
    Pain is late, so waiting means a bigger repair.
  • Avoid: Treating it yourself
    Wart removers and black salve blur the borders.
  • Avoid: Incomplete removal
    Involved margins mean the tumor is still there.
  • Avoid: No skin checks after treatment
    Follow-up finds the next one small.

Habits that help

  • Watch for change, not for existence
    Growing, darkening, bleeding or newly itchy.
  • Then leave it alone
    Avoid picking or rubbing a growth confirmed as benign.
  • Curettage or shave removal
    Precise, and it yields tissue to examine.
  • Daily sunscreen on treated areas
    Keeps the mark from deepening.
  • Discuss how age affects monitoring and recovery
    The biggest driver of how many you get.
  • Tell the clinician about your family history
    Why one person has one growth and another fifty.

Avoid

  • Avoid: Sun exposure
    Adds to the count, and darkens marks after removal.
  • Avoid: Assuming a dark growth is benign
    Melanoma is mistaken for one.
  • Avoid: Picking or peeling one off
    They bleed, inflame, and mark.
  • Avoid: Friction from clothing
    Straps, waistbands and belts irritate growths.
  • Avoid: Shaving over them
    The usual cause of sudden bleeding.
  • Avoid: Home freezing kits and acid pens
    They scar something nobody examined.
  • Avoid: A sudden crop of many new ones
    Many at once should be assessed.
  • Avoid: Removal without a diagnosis
    Destroyed tissue cannot be analyzed.
  • Avoid: Home freezing and acid kits
    Do not freeze or burn unexamined growths at home; tissue may need examination.

Treatment differences

Evidence labels come from each condition’s own treatment list.

Treatment
● Basal Cell Carcinoma
● Seborrheic Keratosis
Filter by type
Diagnosed basal cell carcinoma type

Select one or more.

All types
Over-the-counter
None listed
Five white jars of 40% urea cream lined up, several also listing 2% salicylic acid

Urea

Limited evidence

A strong urea cream can soften and flatten the rough white growths that scatter over the lower legs, called stucco keratoses, if the roughness is what bothers you. It smooths the surface rather than removing the growth, and it has to be used continuously. It does nothing for thick, dark, stuck-on growths elsewhere.

Paula's Choice 2% BHA exfoliant, La Roche-Posay Effaclar cleanser and a CeraVe psoriasis cream pump

Salicylic Acid

Avoid

Wart treatments are often tried on these because the surface looks similar. Salicylic acid can thin the rough top layer, but it does not clear the growth, and it irritates the normal skin around it. The bigger problem is that it is usually being used on something nobody has examined.

Four ointments on white: CeraVe Healing Ointment, a Vaseline jar, a petroleum jelly tube and Aquaphor

Petrolatum

Listed

This is aftercare, not treatment. A thin layer of plain petroleum jelly over a treated spot keeps the scab soft and gives the neatest healing, under a small dressing rather than an adhesive strip. It does nothing to a growth that is still there.

Four mineral sunscreens on white: Native SPF 30, Thinksport SPF 50, Colorescience Flex and EltaMD UV Clear

Zinc Oxide

Listed

Daily mineral sunscreen over a spot that has just been treated stops the temporary mark from darkening and helps it fade faster, which matters most on the face, chest and hands. It will not remove a growth or stop new ones forming. Sun is only one of several things that drive these, and age and family history matter more.

Prescription topicals
None listed

Eskata

Moderate evidence

A high-strength peroxide solution applied in clinic was approved for raised growths on the face and body. It cleared some growths, often needed repeat visits, and commonly caused stinging, crusting and pigment change. It was withdrawn from sale in the United States, so in practice removal is done by hand rather than with a liquid.

Procedures
Editorial illustration for Mohs Surgery, based on the entry’s treatment or equipment reference.

Mohs Surgery

Strong evidence

The tumor is removed in stages and the edges are examined under a microscope during the same appointment, so complete removal is confirmed before the wound is closed. It has the highest cure rate and spares the most normal tissue, which is why it is used on the face and for aggressive subtypes. It takes several hours, and it is not needed for every tumor.

Editorial illustration for Surgical Excision, based on the entry’s treatment or equipment reference.

Surgical Excision

Strong evidence

The tumor is cut out with a margin of normal skin around it and the wound is stitched, with the margins checked by a pathologist afterwards. It is the standard treatment for most tumors away from the face, and it cures the large majority in one visit. If the report comes back with the tumor at the edge, more treatment is needed.

Editorial illustration for Electrodesiccation and Curettage, based on the entry’s treatment or equipment reference.

Electrodesiccation and Curettage

Moderate evidence

The tumor is scraped away and the base burned, repeated a few times in one visit. It suits small, thin, superficial tumors on the trunk and limbs and is quick and cheap. Nothing is checked under a microscope afterwards, so it is not used on the face or for aggressive subtypes, and it leaves a permanent pale round mark.

Editorial illustration for Photodynamic Therapy, based on the entry’s treatment or equipment reference.

Photodynamic Therapy

Moderate evidence

A light-sensitizing cream is left on the tumor and then activated with a lamp, usually in two sessions. It is for thin superficial tumors only, confirmed by biopsy, and it has the advantage of treating the sun-damaged skin around them at the same time. It stings during the light, and the cure rate is lower than surgery.

Editorial illustration for Cryotherapy, based on the entry’s treatment or equipment reference.

Cryotherapy

Moderate evidence

Freezing is quick and occasionally used for small superficial tumors when other options do not suit. Nothing is checked under a microscope, so an incompletely treated tumor can carry on growing under a healed surface. It also leaves a permanent pale patch, which is much more noticeable on deeper skin tones.

Editorial illustration for Skin Biopsy, based on the entry’s treatment or equipment reference.

Skin Biopsy

Listed

A small sample taken under local anesthetic, usually a shave or a punch, and read by a pathologist. It does two things: it confirms this is a basal cell carcinoma, and it names the subtype. The subtype is what decides which treatment is right, so this comes before the treatment conversation rather than after it.

Editorial illustration for Electrodesiccation and Curettage, based on the entry’s treatment or equipment reference.

Electrodesiccation and Curettage

Moderate evidence

The growth is scraped off with a small curette and the base sealed with a fine electric tip. It is controlled and shallow, which is why it is often preferred for small facial growths and for the dark facial growths common on deeper skin tones. Scraping first still gives tissue that can be examined if there is doubt.

Editorial illustration for Cryotherapy, based on the entry’s treatment or equipment reference.

Cryotherapy

Moderate evidence

A few seconds of liquid nitrogen makes flatter growths blister and lift off over a week or two, and it is the quickest way to treat several at once. It destroys the growth, so nothing can be examined afterward, which is why it is not used on anything with a question attached. It is used cautiously on the face and on deeper skin tones, because the pigment cells are sensitive to cold and it can leave a pale spot.

Editorial illustration for Skin Biopsy, based on the entry’s treatment or equipment reference.

Skin Biopsy

Listed

When a growth is changing, bleeding on its own, or simply looks unlike your others, part or all of it is taken after numbing and examined under a microscope. It is the only way to be certain, and the threshold for doing it is deliberately low, because the cost of a small biopsy is trivial next to missing a melanoma. An irritated growth is one of the commonest reasons a benign growth ends up being sampled.

Editorial illustration for Shave Removal, based on the entry’s treatment or equipment reference.

Shave Removal

Moderate evidence

The growth is numbed and shaved off level with the skin in a few seconds. It is the method of choice when there is any question about what a growth is, because it produces tissue that can be sent to the laboratory. It leaves a flat mark that fades over months, and it does not stop new growths appearing elsewhere.

Editorial illustration for Fractional CO2 Laser, based on the entry’s treatment or equipment reference.

Fractional CO2 Laser

Limited evidence

An ablative laser can vaporise a growth precisely and is sometimes used when several need treating on the face. Like freezing, it destroys the tissue, so it is only for growths already confirmed as harmless. It is the most expensive of the options and it is not better than a curette for a single growth.

Outlook

Long term

Basal cell carcinoma is slow, which is why it gets lived with for too long. It grows in one place over months and years, and the heal-and-return cycle is what finally gets it noticed.

Seborrheic keratoses appear slowly, change slowly, then stay. Two departures deserve attention: one growth that starts changing - growing, darkening, bleeding on its own, or itching persistently - and a sudden crop of many new ones over weeks to months.

Complications

Possible complications
  • The most useful clue there is
  • It keeps invading nearby tissue
More details

The most useful clue there is
It scabs, bleeds when knocked, shaved over or towel-dried, appears to heal, then breaks down in the same place. People read that cycle as improvement.

It keeps invading nearby tissue
On the nose, eyelid, ear and lip it can reach cartilage and deeper structures, and the repair needed becomes far larger. Ulceration, bleeding and a persistent open area are late features. Some subtypes track along nerves, causing numbness or tingling. Spread to lymph nodes or other organs happens, but is genuinely rare.

  • Catching on clothing makes it flare
More details

Catching on clothing makes it flare
A growth caught by clothing, a strap or a waistband can turn red, swollen, itchy, crusted or sore, and can bleed. That is an irritated seborrheic keratosis. It settles, but it looks alarming and often prompts removal or a sample.

When to get help

When to get help

Arrange assessment of a persistent pearly bump, ulcer or repeatedly bleeding sore. It usually grows locally and needs treatment rather than observation alone.

Have a new, changing, bleeding or uncertain growth assessed; skin cancer can sometimes resemble a harmless stuck-on growth.

Common questions

Basal Cell Carcinoma:Is basal cell carcinoma dangerous?

Rarely dangerous to your life, because it almost never spreads to other organs. It is a real risk to the tissue around it, it keeps growing, and it does not resolve, so the question is not whether to treat but how soon. Earlier means a smaller procedure.

Basal Cell Carcinoma:How fast does it grow?

Slowly, over months to years, which is why it gets left. The slowness is why early treatment works so well: a tumor caught at a few millimeters on the nose is a short procedure, and the same tumor two years later can need reconstruction.

Basal Cell Carcinoma:What is Mohs surgery and do I need it?

The tumor is removed in stages and the edges examined under a microscope at the same appointment, so complete removal is confirmed before closing. It spares the most normal tissue and is used mainly on the face and for higher-risk tumors. Ask why a method is recommended for yours.

Basal Cell Carcinoma:Can I just use a cream instead of surgery?

Sometimes, for thin superficial tumors on the trunk or limbs, and only after a biopsy has shown that subtype. Cure rates are lower, treatment runs for weeks, and the skin gets red, sore and crusted while it works. A trade-off, not an easier option.

Basal Cell Carcinoma:Will I get another one?

A large proportion do, usually within about five years and elsewhere on sun-damaged skin. Not a sign the first treatment failed - it is why skin checks and daily sun protection are part of the plan.

Basal Cell Carcinoma:Will it leave a scar?

Yes. Every treatment leaves a mark, and how it looks depends on the site and the method. If you have ever had a thickened or keloid scar, say so beforehand; it can change the technique and closure. Silicone and sun protection help once it has healed.

Seborrheic Keratosis:Could this be melanoma?

It could be, which is why it should be looked at rather than diagnosed at home. Melanoma is sometimes mistaken for a seborrheic keratosis, and a dermatoscope resolves most of these in seconds. The concerning features are change in size, shape or color, bleeding without being knocked, an irregular edge, and a growth unlike your others. Book rather than watch.

Seborrheic Keratosis:Why am I suddenly getting so many?

Age and family history account for nearly all of it. They accumulate steadily from the forties onward, and someone whose parents had many will develop many. A genuinely sudden crop over weeks to months, especially with itching, is different and worth examining.

Seborrheic Keratosis:Does removing one stop more from appearing?

No. Removal deals with that growth, not the age and inherited tendency behind it, so new ones can keep appearing elsewhere. That is expected, not a failed removal.

Seborrheic Keratosis:Will removal leave a mark?

Often, at least for a while. A flat spot darker or paler than nearby skin is common, and dark marks usually fade over months. Pale marks can be permanent and are more noticeable on deeper skin tones, so ask about the method and do a test spot before treating a large area. Daily sunscreen on the treated spot makes a real difference.

Seborrheic Keratosis:Mine got red and itchy and started bleeding. What happened?

Most likely it caught on clothing, a strap or a razor and became an irritated seborrheic keratosis. They look far worse than they are and they settle. Still have it looked at - an irritated growth is one of the harder ones to be sure about by appearance, and a growth that bled with nothing catching it is a different question.

Seborrheic Keratosis:Can I have them all removed?

As many as you and your doctor think sensible, usually in sessions rather than all at once. It is normally considered cosmetic, so ask about cost first. On the face, and particularly on deeper skin tones, start with a small test area and see how it heals.

Sources

Sources and further reading

  1. DermNet
  2. DermNet
Dermapedia on YouTube