Moles vs Seborrheic Keratosis

Moles are ordinary clusters of pigment cells in the skin, and almost all of them stay harmless for a whole lifetime. What matters is not how many you have, but whether one of them is changing - because a changing mole is the earliest sign of melanoma, and the earliest melanoma is the one that is easiest to cure. A seborrheic keratosis is a common, harmless growth that looks stuck onto the skin, like a piece of wax or a small barnacle. They are not cancer and they do not become cancer. The reason to see a doctor is to be sure that is what you are looking at.

Reviewed by Dr. Schwarz, Board-Certified Dermatologist · Research updated 2026-10-23
Several small tan to mid-brown moles on the shoulder and upper arm of an adult with light skin, each evenly colored with smooth edges, with one larger mole among them.Two growths on the upper back on fair skin. One is a flat light tan patch and the other is a raised mid-brown growth with a rough waxy surface and a sharply defined edge.

Key differences

The same eight facts on every condition comparison.

Usual age
Childhood and teens
40 and over
Where
Anywhere
Back, chest, face
Main sign
Even brown spots or bumps
Waxy stuck-on growth
Itch or pain
No
Sometimes itchy
Contagious
No
No
Long term
Harmless; watch for change
Stays; more appear
Scars
No
No
Who gets it
Everyone; more in fair skin
Most people over 50

What is it?

Moles
Seborrheic Keratosis
What is it?

They are clusters of pigment cells.
Moles are usually benign collections of melanocytes.

They vary in appearance.
They can be flat or raised, skin-colored or pigmented.

They appear at different times.
Some are present at birth; others appear later.

New or changing moles need a check.
A stable familiar mole differs from an evolving lesion.

It is a benign growth.
Surface skin cells form a waxy, warty or stuck-on growth.

Color varies.
It can be tan, brown, gray or almost black.

It is not a precancer.
These growths become more common with age.

Uncertain lesions are tested.
Tissue is examined before any destructive treatment if the appearance is unclear.

What it looks like

Moles

Common brown mole on the arm.

Common mole Small, round, even color.

Representative image of irregular pigmented spot. It illustrates a visible feature or experience and is not a diagnostic reference.

Atypical mole Larger, uneven border or color.

Large congenital mole on a child's back.

Congenital mole Present from birth.

Generated image: Mole surrounded by a white ring of skin. Not a patient photograph.

Halo nevus Generated illustration. Mole surrounded by a pale ring.

Small blue-gray mole on the hand.

Blue nevus Small blue-gray mole.

Seborrheic Keratosis

Close view of a rough hyperkeratotic brown stuck-on lesion, representing seborrheic keratosis.

Classic seborrheic keratosis Raised, waxy, stuck-on growth.

Multiple small gray-white raised bumps on the lower legs, representing stucco keratoses.

Stucco keratosis Small white-gray bumps on the legs.

Small dark raised papules on brown cheek skin, representing dermatosis papulosa nigra.

Dermatosis papulosa nigra Small dark bumps on the face.

Skin tones
Several small tan to mid-brown moles on the shoulder and upper arm of an adult with light skin, each evenly colored with smooth edges, with one larger mole among them.
Several mid to dark brown moles on the shoulder and upper arm of an adult with medium olive-toned skin, with one larger mole that is uneven in shape.
Several dark brown to near-black moles on the shoulder and upper arm of an adult with brown skin, each small, evenly colored and smooth-edged, on even-toned surrounding skin.
Several dark brown to near-black moles on the shoulder and upper arm of an adult with deep brown skin, each small, evenly colored and smooth-edged.
Two growths on the upper back on fair skin. One is a flat light tan patch and the other is a raised mid-brown growth with a rough waxy surface and a sharply defined edge.
A raised brown growth on the chest on medium olive skin. Its color is only slightly deeper than the surrounding skin, but the rough waxy surface and the sharply drawn edge are clearly visible.
Several small, dark brown to black raised growths scattered over the cheek and temple on brown skin, ranging from one to three millimetres across, on otherwise even-toned skin.
A cluster of black raised growths along the side of the neck on deep brown skin, each with a sharply defined edge, with two flat darker marks nearby where earlier growths were treated.
Diagram
Moles mechanism diagram. A spot or bump is visible: Many moles are flat, while others are raised. Pigment cells cluster: Nevus cells form small organized nests. Some nests sit in the dermis: Different mole types have different arrangements.
Seborrheic Keratosis mechanism diagram. A stuck-on plaque appears: The surface can look waxy or rough. Keratin collects in the growth: Tiny keratin-filled spaces may form. Surface cells grow locally: A benign epidermal growth develops.
In the skin

Moles form when benign pigment cells cluster into small nests. The location and arrangement of these cells help explain why some moles are flat and others are raised.

A benign overgrowth of surface skin cells creates a localized plaque. Keratin and sometimes pigment collect in the growth, giving it a waxy, rough or stuck-on appearance.

Where it shows up

Any skin site
Variable sites, often trunk or face

When it usually starts

010203040506070+

Moles. Most ordinary moles appear during childhood and adolescence; new or changing adult lesions deserve attention.

Seborrheic Keratosis. Usually appears in adult life and becomes increasingly common with age.

Causes and triggers

Causes

Moles form when pigment cells grow in a cluster instead of spreading through the skin. Most appear in childhood and early adulthood.

Seborrheic keratoses are harmless growths of skin cells that become more common with age.

Family tendency

The number of moles you have is largely inherited.

They often run in families.

Risk factors
Fair skin, Family history of many moles, Childhood sunburns
Age over 50, Family history, Sun exposure
Trigger
● Moles
● Seborrheic Keratosis
Sun exposure in childhood
Strong link
Not listed
Pregnancy
Possible
Not listed
Aging
Not listed
Well established
Sun exposure
Not listed
Possible

Daily Care

Moles
Seborrheic Keratosis
Daily care

Habits that help

  • Learn the ABCDE signs
    Asymmetry, Border, Color, Diameter, Evolving — the one that matters most.
  • Learn the ugly duckling sign
    The mole that does not belong in the family.
  • Check your own skin about once a month
    Include back, scalp, soles, palms and nails.
  • Take photographs
    Comparison over months beats memory.
  • Use sunscreen daily on exposed skin
    Broad spectrum, SPF 30 or higher, reapplied outdoors.
  • Use shade, clothing and hats
    A long-sleeved shirt outperforms any bottle.
  • Never use a tanning bed
    No protective base tan, no safe dose.
  • Protect children from burning
    Risk is largely set before adulthood.
  • Discuss skin surveillance if your immune system is weakened
    Immune-suppressing treatment raises skin cancer risk.

Avoid

  • Avoid: Sunburn
    Raises mole count and damages the cells inside.
  • Avoid: Tanning beds
    A concentrated dose of the damaging wavelengths.
  • Avoid: Intense occasional sun
    Holiday exposure matters more than steady daily sun.
  • Avoid: Skipping sunscreen in cloud and winter
    Ultraviolet passes cloud and reflects off snow.
  • Avoid: Assuming a painless mole is fine
    Pain and itch are late signs.
  • Avoid: Only checking the parts you can see easily
    Scalp, back, buttocks, soles and nails all count.
  • Avoid: Relying on a phone app
    A reassuring result is no reason to cancel.
  • Avoid: Being told once that a mole is fine
    A mole examined five years ago was fine five years ago.
  • Avoid: A mole-checking phone app
    Use photos to track changes; never delay an examination because an app gives reassurance.
  • Avoid: Mole removal creams and kits
    Do not burn, freeze or dissolve moles at home; the tissue may need examination.
  • Avoid: Waiting to see if a change settles down
    Three months of waiting is three months of growth.
  • Avoid: Cryotherapy
    Freezing is excellent for several other skin growths and is the wrong tool for a mole. It destroys the tissue, so nothing can be examined, and it commonly leaves the deeper pigment cells behind along with a pale mark. Lasering or burning a mole off has the same two problems. If a mole is worth removing, it is worth removing in a way that can be checked.

Habits that help

  • Watch for change, not for existence
    Growing, darkening, bleeding or newly itchy.
  • Then leave it alone
    Avoid picking or rubbing a growth confirmed as benign.
  • Curettage or shave removal
    Precise, and it yields tissue to examine.
  • Daily sunscreen on treated areas
    Keeps the mark from deepening.
  • Discuss how age affects monitoring and recovery
    The biggest driver of how many you get.
  • Tell the clinician about your family history
    Why one person has one growth and another fifty.

Avoid

  • Avoid: Sun exposure
    Adds to the count, and darkens marks after removal.
  • Avoid: Assuming a dark growth is benign
    Melanoma is mistaken for one.
  • Avoid: Picking or peeling one off
    They bleed, inflame, and mark.
  • Avoid: Friction from clothing
    Straps, waistbands and belts irritate growths.
  • Avoid: Shaving over them
    The usual cause of sudden bleeding.
  • Avoid: Home freezing kits and acid pens
    They scar something nobody examined.
  • Avoid: A sudden crop of many new ones
    Many at once should be assessed.
  • Avoid: Removal without a diagnosis
    Destroyed tissue cannot be analyzed.
  • Avoid: Home freezing and acid kits
    Do not freeze or burn unexamined growths at home; tissue may need examination.

Treatment differences

Evidence labels come from each condition’s own treatment list.

Treatment
● Moles
● Seborrheic Keratosis
Over-the-counter
None listed
Five white jars of 40% urea cream lined up, several also listing 2% salicylic acid

Urea

Limited evidence

A strong urea cream can soften and flatten the rough white growths that scatter over the lower legs, called stucco keratoses, if the roughness is what bothers you. It smooths the surface rather than removing the growth, and it has to be used continuously. It does nothing for thick, dark, stuck-on growths elsewhere.

Paula's Choice 2% BHA exfoliant, La Roche-Posay Effaclar cleanser and a CeraVe psoriasis cream pump

Salicylic Acid

Limited evidence

Wart treatments are often tried on these because the surface looks similar. Salicylic acid can thin the rough top layer, but it does not clear the growth, and it irritates the normal skin around it. The bigger problem is that it is usually being used on something nobody has examined.

Four ointments on white: CeraVe Healing Ointment, a Vaseline jar, a petroleum jelly tube and Aquaphor

Petrolatum

Listed

This is aftercare, not treatment. A thin layer of plain petroleum jelly over a treated spot keeps the scab soft and gives the neatest healing, under a small dressing rather than an adhesive strip. It does nothing to a growth that is still there.

Four mineral sunscreens on white: Native SPF 30, Thinksport SPF 50, Colorescience Flex and EltaMD UV Clear

Zinc Oxide

Listed

Daily mineral sunscreen over a spot that has just been treated stops the temporary mark from darkening and helps it fade faster, which matters most on the face, chest and hands. It will not remove a growth or stop new ones forming. Sun is only one of several things that drive these, and age and family history matter more.

Prescription topicals
None listed

Eskata

Moderate evidence

A high-strength peroxide solution applied in clinic was approved for raised growths on the face and body. It cleared some growths, often needed repeat visits, and commonly caused stinging, crusting and pigment change. It was withdrawn from sale in the United States, so in practice removal is done by hand rather than with a liquid.

Procedures
Editorial illustration for Surgical Excision, based on the entry’s treatment or equipment reference.

Surgical Excision

Strong evidence

The standard for any mole that is genuinely in doubt: the whole mole is cut out under local anesthetic with a narrow margin of normal skin and sent for examination under a microscope. Taking all of it matters, because the pathologist has to see the full depth and the edges. It leaves a line scar, and results come back in a week or two.

Editorial illustration for Shave Removal, based on the entry’s treatment or equipment reference.

Shave Removal

Moderate evidence

A raised mole that catches on a razor or a collar can be shaved off flush with the skin under local anesthetic, leaving a flat pale mark rather than a line scar. It is a reasonable choice for a mole that is not suspicious, and the tissue still goes to the laboratory. Two honest limits: pigment left at the base can grow back, and a shave through a melanoma cuts across it rather than under it.

Editorial illustration for Punch Biopsy, based on the entry’s treatment or equipment reference.

Punch Biopsy

Listed

A small circular blade removes a small mole whole, down through the full thickness of the skin, and it is closed with a stitch or two. It suits moles smaller than the punch. Used to take a sample from part of a larger suspicious mole it can under-read the depth, so for those an excision is the better choice.

Editorial illustration for Shave Removal, based on the entry’s treatment or equipment reference.

Shave Removal

Moderate evidence

The growth is numbed and shaved off level with the skin in a few seconds. It is the method of choice when there is any question about what a growth is, because it produces tissue that can be sent to the laboratory. It leaves a flat mark that fades over months, and it does not stop new growths appearing elsewhere.

Editorial illustration for Electrodesiccation and Curettage, based on the entry’s treatment or equipment reference.

Electrodesiccation and Curettage

Moderate evidence

The growth is scraped off with a small curette and the base sealed with a fine electric tip. It is controlled and shallow, which is why it is often preferred for small facial growths and for the dark facial growths common on deeper skin tones. Scraping first still gives tissue that can be examined if there is doubt.

Editorial illustration for Cryotherapy, based on the entry’s treatment or equipment reference.

Cryotherapy

Moderate evidence

A few seconds of liquid nitrogen makes flatter growths blister and lift off over a week or two, and it is the quickest way to treat several at once. It destroys the growth, so nothing can be examined afterward, which is why it is not used on anything with a question attached. It is used cautiously on the face and on deeper skin tones, because the pigment cells are sensitive to cold and it can leave a pale spot.

Editorial illustration for Fractional CO2 Laser, based on the entry’s treatment or equipment reference.

Fractional CO2 Laser

Limited evidence

An ablative laser can vaporise a growth precisely and is sometimes used when several need treating on the face. Like freezing, it destroys the tissue, so it is only for growths already confirmed as harmless. It is the most expensive of the options and it is not better than a curette for a single growth.

Editorial illustration for Skin Biopsy, based on the entry’s treatment or equipment reference.

Skin Biopsy

Listed

When a growth is changing, bleeding on its own, or simply looks unlike your others, part or all of it is taken after numbing and examined under a microscope. It is the only way to be certain, and the threshold for doing it is deliberately low, because the cost of a small biopsy is trivial next to missing a melanoma. An irritated growth is one of the commonest reasons a benign growth ends up being sampled.

Outlook

Long term

Most moles remain harmless, but their appearance can change over a lifetime. A changing mole, a new unusual pigmented spot or one that looks different from the others needs examination. Monitoring should follow the person's individual risk.

Seborrheic keratoses appear slowly, change slowly, then stay. Two departures deserve attention: one growth that starts changing - growing, darkening, bleeding on its own, or itching persistently - and a sudden crop of many new ones over weeks to months.

Complications

Possible complications

Most moles are benign. Having many or atypical moles can mark increased melanoma risk, and a changing lesion should be examined rather than assumed to be an ordinary mole.

  • Catching on clothing makes it flare
More details

Catching on clothing makes it flare
A growth caught by clothing, a strap or a waistband can turn red, swollen, itchy, crusted or sore, and can bleed. That is an irritated seborrheic keratosis. It settles, but it looks alarming and often prompts removal or a sample.

When to get help

When to get help

Arrange prompt assessment for an evolving, unusual or bleeding mole. Comparing a spot with your other moles is useful, but photographs cannot confirm a diagnosis.

Have a new, changing, bleeding or uncertain growth assessed; skin cancer can sometimes resemble a harmless stuck-on growth.

Common questions

Moles:How do I tell a normal mole from a dangerous one?

Use two checks together. ABCDE covers asymmetry, an uneven border, more than one color, a diameter above about 6 millimeters, and - most important - evolving, meaning changing. The ugly duckling check asks whether the mole looks like your others. A spot that fails either, or passes both but keeps changing, should be examined in person.

Moles:Is it normal to get new moles as an adult?

New moles keep appearing through the teens and twenties and become uncommon after about 40. Many new pigmented spots in older adults turn out to be seborrheic keratoses or sun spots. That is a reason to have a new spot identified, not to assume it is one of those.

Moles:Can I have a mole removed just because I do not like it?

Yes, and it is a reasonable request. What matters is how it is done — cut out under local anesthetic and sent to a laboratory. Lasering, freezing or burning leaves nothing to examine, so ask for the version that gets checked.

Moles:Does having a lot of moles mean I will get melanoma?

No. Your risk is higher than average and regular checks are worth doing, but most people with a high mole count never develop melanoma. The response is a schedule of skin exams, not worry.

Moles:Can melanoma appear where there was no mole?

Yes — most melanomas arise on skin that had no mole before. That is why a new spot that grows, or a sore that will not heal, deserves the same attention as a changing mole.

Moles:My mole changed during pregnancy. Is that expected?

Moles commonly darken slightly in pregnancy, and skin stretching over a growing abdomen or breasts can change a mole's shape. Melanoma does occur in pregnancy, though. A mole that changes in shape, border or color should be looked at while you are pregnant, not after.

Seborrheic Keratosis:Could this be melanoma?

It could be, which is why it should be looked at rather than diagnosed at home. Melanoma is sometimes mistaken for a seborrheic keratosis, and a dermatoscope resolves most of these in seconds. The concerning features are change in size, shape or color, bleeding without being knocked, an irregular edge, and a growth unlike your others. Book rather than watch.

Seborrheic Keratosis:Why am I suddenly getting so many?

Age and family history account for nearly all of it. They accumulate steadily from the forties onward, and someone whose parents had many will develop many. A genuinely sudden crop over weeks to months, especially with itching, is different and worth examining.

Seborrheic Keratosis:Does removing one stop more from appearing?

No. Removal deals with that growth, not the age and inherited tendency behind it, so new ones can keep appearing elsewhere. That is expected, not a failed removal.

Seborrheic Keratosis:Will removal leave a mark?

Often, at least for a while. A flat spot darker or paler than nearby skin is common, and dark marks usually fade over months. Pale marks can be permanent and are more noticeable on deeper skin tones, so ask about the method and do a test spot before treating a large area. Daily sunscreen on the treated spot makes a real difference.

Seborrheic Keratosis:Mine got red and itchy and started bleeding. What happened?

Most likely it caught on clothing, a strap or a razor and became an irritated seborrheic keratosis. They look far worse than they are and they settle. Still have it looked at - an irritated growth is one of the harder ones to be sure about by appearance, and a growth that bled with nothing catching it is a different question.

Seborrheic Keratosis:Can I have them all removed?

As many as you and your doctor think sensible, usually in sessions rather than all at once. It is normally considered cosmetic, so ask about cost first. On the face, and particularly on deeper skin tones, start with a small test area and see how it heals.

Sources

Sources and further reading

  1. DermNet
  2. DermNet
Dermapedia on YouTube