Oily skin & pores
Moderate2% reduced oil in studies.
The gentle all-rounder. A form of vitamin B3 that strengthens the skin barrier, softens dark spots and calms oil and redness.
Medical review pending
Review date to come
Key Facts
B3
A water-soluble form of vitamin B3.
2–5%
The strengths used in most studies.
4–8 wks
To notice less oil and redness.
All skin
Well tolerated by most skin types.
What Is It?
Your skin cells turn niacinamide into NAD+, which they need for energy and repair. Applied to skin, it helps cells build ceramides — the fats that hold the barrier together.
The molecule
122 Da · very small
Water
Nicotinamide
Light and air
Often Used For
2% reduced oil in studies.
5% lightened spots over 8 weeks.
4% gel similar to 1% clindamycin.
Boosts ceramides.
Calming in small studies.
Modest smoothing at 5%.
How It Works · Interactive
A thin layer sits on the surface.
Tiny and water-loving, it passes the outer layer easily.
Cells make more ceramides; water stays in.
Barrier repair
It slows pigment transfer to skin cells.
Hyperpigmentation
Inflammation and oil production drop.
Types & Related Ingredients
Topical form in skincare. Gentle, no flushing.
Same molecule, taken for skin cancer prevention.
Nicotinic acid; causes hot, red flushing.
Popular pairing for oil and blemishes.
Forms & Strengths
Highlighted: the strength most people start with.
Most concentrated.
Easiest way in.
Daytime bonus.
Rinsed off — least benefit.
Recommended Products
Budget serum.
Mixes into moisturizer.
Niacinamide plus ceramides.
Gentle daily moisturizer.
Safety & Side Effects
Tip. Considered safe in pregnancy and breastfeeding.
How to Use It
Gentle cleanser; pat dry.
Over the whole face.
Once the serum has dried.
Essential for dark spots.
Tip. New to actives? Patch test on your jaw for 3 nights.
Pairing With Other Ingredients
Helps offset retinoid dryness.
Hydration plus barrier repair.
Protects your results.
Fine together; the old myth is outdated.
A solid acne team.
May sting; alternate nights.
Results & What to Expect
Skin feels more comfortable.
Less shine and calmer redness.
Dark spots start to fade.
Smoother, more even tone.
Alternatives
If…
it stings or feels warm
If…
dark spots are your main goal
If…
you want anti-aging results
Common Questions
Yes. Modern formulas are fine together.
Not necessarily. Most studies used 2–5%.
It can make them look smaller by reducing oil.
Either, or both.
Dermapedia is for education only and is not medical advice. It does not create a doctor–patient relationship. Always consult a qualified clinician about your own skin.