Acne photo
Acne
StrongFirst-line for clogged pores and pimples.
Also called Differin, Epiduo (with benzoyl peroxide)
The gentle retinoid you can buy without a prescription. Unclogs pores and prevents new breakouts with less irritation than tretinoin.
Medical review pending
Review date to come
Key Facts
2016
Became available over the counter in the US.
0.1%
The OTC strength.
12 wks
To judge acne results.
OTC
No prescription for 0.1%.
What Is It?
Adapalene is a lab-designed retinoid. It targets the retinoid receptors that control pore-clogging more selectively than tretinoin, which makes it gentler and more stable.
Retinoid family
OTC
OTC · Rx
Rx
Rx
Often Used For
First-line for clogged pores and pimples.
Blackheads and whiteheads.
Faster turnover fades marks.
Less studied than tretinoin.
Some smoothing.
Off-label.
How It Works · Interactive
Enough for the whole face.
It concentrates in pores, where acne starts.
Only the receptors that control pore lining.
Retinoid receptors
Pore cells shed normally again.
Acne
Fewer red, angry spots.
Forms & Dosing
Highlighted: the strength most people start with.
Light; good for oily skin.
For dry or sensitive skin.
Easy on the chest and back.
Safety & Side Effects
Important. Avoid during pregnancy or when trying to conceive.
How to Use It
Wait 10 minutes if you sting.
Thin layer over the whole area.
Once it’s absorbed.
Every day.
Tip. Treat the whole area, not just spots — it prevents new ones.
Interactions & What to Avoid
Stable together; a proven combo.
Soothe dryness.
Alternate nights.
Skin can lift.
Not recommended.
Monitoring & Follow-Up
Baseline photos.
Early flare should be settling.
Judge results; consider Rx options if needed.
Results & What to Expect
Mild dryness; possible purge.
Fewer new breakouts.
Clearer skin.
Keep using to stay clear.
Access & Cost
0.1% gel, no prescription.
[$/tube]
For 0.3% or combination gels.
[$ visit]
Combination formulas shipped home.
[$/month]
Alternatives
If…
it’s too drying
If…
you’re pregnant
If…
acne is severe or scarring
Common Questions
Adapalene is gentler and OTC; tretinoin is stronger and better for aging.
Many people can; go every other night if you’re dry.
Possibly, but tretinoin has far more evidence.
About 12 weeks.
Dermapedia is for education only and is not medical advice. It does not create a doctor–patient relationship. Always consult a qualified clinician about your own skin.