Letybo
A neurotoxin injection at the forehead. Several small injections are placed across the muscle rather than one large one in the middle.
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Letybo vs Xeomin
Both are botulinum toxin type A, and both smooth the frown lines between the brows. The real split is coverage: Xeomin is also approved for the forehead and crow's feet, and Letybo is not. Letybo is newer here and is often offered at a lower price. No trial has ever compared the two.
At a glance
| The difference | Letybo | Xeomin |
|---|---|---|
| Cost | Often offered at a lower price | Priced per unit, out of pocket |
Xeomin
A neurotoxin injection at the inner brow. Xeomin carries no accessory proteins around the toxin, which is the one real difference from the others at the point of injection.
Side by side
The differences that matter
What you actually do
Letybo
Several small shots, a few minutes
Small injections into the muscle. How many shots you get depends on how many areas are treated, not on the brand.
Xeomin
Several small shots, a few minutes
The same visit and the same needle. Xeomin can be used across the upper face in one session.
What you can expect to see
Letybo
Softer frown lines
The vertical lines between the brows relax. That is the only approved area.
Xeomin
Softer lines across the upper face
The same effect between the brows. It is also used on the forehead and around the eyes.
The dose for frown lines
Letybo
20 units
Given as five small shots.
Xeomin
20 units
Also five small shots.
Cost
Letybo
Often offered at a lower price
You pay for this yourself. Insurance does not cover it.
Xeomin
Priced per unit, out of pocket
A price per unit tells you nothing across brands, because a unit of one is not a unit of the other. Ask for the price of the whole visit.
The at-home or drugstore version
Letybo
No home version exists
Creams and serums sold as "Botox in a bottle" sit on the surface of the skin. The muscle that makes a frown line is several millimetres down. A cream cannot reach it.
Xeomin
No home version exists
The same answer. Xeomin is placed in the muscle by an injector, and nothing sold over the counter does that.
Who tends to be happy with it
Letybo
- Best for — Frown lines, especially where the price is lower.
- The mindset — One area, one product.
Xeomin
- Best for — Anyone treating the forehead or crow's feet too.
- The mindset — You want the treatment to sit inside the approved use.
Why the forehead is the deciding question
Xeomin
Xeomin is one of only two brands approved for the whole upper third of the face. Botox Cosmetic is the other. Letybo is not, and neither are Dysport, Jeuveau or Daxxify.
The idea that Xeomin works when other toxins stop working
Xeomin
Xeomin has no helper proteins around the toxin. Most brands wrap the toxin in extra proteins. Xeomin does not, and that is the basis of the claim: fewer foreign proteins give the immune system less to react to.
Xeomin is not the only bare toxin. Daxxify has no helper proteins either. If the argument holds, it holds for both.
The fine print
Letybo
Letybo (letibotulinumtoxinA-wlbg) is approved in the US for glabellar frown lines only, at 20 units given as five injections of 4 units. It holds no therapeutic indications in the US. FDA approval came in 2024 and US launch followed in 2025. Approval rested on three placebo-controlled trials in about 1,270 subjects.
Xeomin
Xeomin (incobotulinumtoxinA) is approved for glabellar lines, horizontal forehead lines and lateral canthal lines. The forehead and crow's feet indications were added in July 2024. The forehead indication is 20 units in five injections of 4 units, and applies only when the glabellar lines are treated concurrently. The label caps combined treatment of all three upper-face areas at 64 units per session. Xeomin has been in US use since 2010 and also holds therapeutic indications including cervical dystonia and chronic sialorrhea.
Common questions
Questions Patients Ask
Is Xeomin better than Letybo?
They have never been compared in a trial, so no one can say. The one clear, factual difference is that Xeomin is approved for forehead lines and crow's feet as well as frown lines, and Letybo is approved for frown lines only. Botox Cosmetic holds those same three approvals.
Do they use the same dose?
For frown lines, yes — both use 20 units in five injections of 4 units. That match is a coincidence of how each brand set its own scale, not a sign they are equivalent. Units still cannot be converted between brands.
What does "no complexing proteins" mean?
Xeomin has the helper proteins that normally surround the toxin removed. Letybo keeps them. Xeomin's form is sometimes said to be less likely to trigger the immune response that makes a toxin stop working, though the evidence for that is not strong.
I have stopped responding to my usual toxin. Will Xeomin work?
It may be worth trying, and injectors do switch people to it for this reason. There is no reliable evidence guaranteeing it will work. Discuss it with your injector rather than assuming.
Is Letybo new?
In the United States, yes — approved in 2024 and launched in 2025. It was used in South Korea and other markets before that.
Can Letybo be used on the forehead?
Injectors can and do use it there, but it is off-label. In the US, Letybo's only approved use is frown lines.
Safety to keep in mind
Treating the forehead is off-label for nearly every brand. That is normal, legal and very common. It does mean the FDA never reviewed the dose or the safety data for that area.
If you are treating frown lines only, none of this affects you. Both are approved for that area.
Which safety warning should I know?
Botulinum toxin can cause drooping or weakness. Seek urgent care for trouble swallowing or breathing. Discuss the specific product’s warnings with your injector.