Letybo
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Letybo vs Daxxify
Letybo is the lower-cost way to treat frown lines. It is a botulinum toxin type A, approved in the US for the lines between the eyebrows. Daxxify is the one with a published duration figure. In its trials, half the people treated still had none-or-mild frown lines at about 24 weeks. The two have never been tested against each other.
At a glance
| The difference | Letybo | Daxxify |
|---|---|---|
| What else is in the vial | Human serum albumin and a protein complex | A stabilising peptide, no albumin |
| Cost | Entered the market as a lower-cost option | Launched at a premium, then reduced |
Daxxify
A few small shots, 40 units in total The dose is split into five injections in the same way.
Side by side
The differences that matter
What you actually do
Letybo
A few small shots, 20 units in total
The dose is split into five injections across the frown lines.
Daxxify
A few small shots, 40 units in total
The dose is split into five injections in the same way.
What you can expect to see
Letybo
Softer frown lines
Tested against placebo, not another brand.
Daxxify
Softer frown lines
Also tested against placebo, not another brand.
More photographs
Letybo
A neurotoxin injection at the forehead. Several small injections are placed across the muscle rather than one large one in the middle.
What it will not do
Letybo
Not for forehead lines or crow's feet
In the US, Letybo is for the frown lines between the eyebrows only.
Daxxify
Not for forehead lines or crow's feet
Daxxify covers the same frown lines. It is also used for a neck muscle condition called cervical dystonia. That is not a cosmetic use.
How long it lasts
Letybo
No duration figure published
Letybo's trials measured the result on fixed dates. They did not report a duration.
Daxxify
About 24 weeks in a published analysis
Half the people treated still had none-or-mild frown lines at that point.
What else is in the vial
Letybo
Human serum albumin and a protein complex
Albumin is a protein from human blood. Most brands use it.
Daxxify
A stabilising peptide, no albumin
Daxxify is the only main brand without it.
Cost
Letybo
Entered the market as a lower-cost option
Daxxify
Launched at a premium, then reduced
The price was cut within about a year of launch.
The at-home or drugstore version
Letybo
No home version of the injection
"Botox in a bottle" serums are sold everywhere. But a cream sits on the surface of the skin. It cannot reach a muscle several millimetres down.
Daxxify
No home version of the injection
The same is true here. Nothing sold over the counter places a toxin into a muscle.
Who tends to be happy with it
Letybo
- Best for — People treating frown lines who want to keep the cost down.
- The mindset — The three to four months most toxins give you is fine.
Daxxify
- Best for — People who would rather come back less often.
- The mindset — Fewer visits is worth paying for.
The fine print
Letybo
Letybo is made by Hugel. It was approved in the US in 2024 and launched in 2025, for glabellar (frown) lines only. The labelled dose is 20 units, given as five injections of 4 units.
Daxxify
Daxxify is made by Revance and was approved in the US in 2022, for glabellar lines and for cervical dystonia. The labelled dose for frown lines is 40 units, given as five injections of 8 units. The 24-week figure comes from a published analysis; it is not on the label, which gives no duration.
Neither product is approved in the US for forehead lines or crow's feet.
Both labels state that their units cannot be converted into any other product's units. The unit scales are unrelated, so the dose numbers say nothing about relative strength.
Common questions
Questions Patients Ask
Does Daxxify last longer than Letybo?
Nobody knows. Daxxify has a published duration figure — a median of about 24 weeks in its own trials — and Letybo has none, because its trials were not designed to measure duration. That is a difference in what was studied, not evidence that one wears off sooner. The two have never been compared directly.
Why does Daxxify use twice as many units?
Because a unit means something different in each brand. Both labels state their units cannot be converted into another product's units. The count is not a measure of strength.
Which is cheaper?
Letybo entered the US as a lower-cost option and Daxxify launched at a premium, though Daxxify's price was reduced within about a year. What you actually pay depends on the clinic. Ask for the whole-treatment price.
Is Letybo as safe as Daxxify?
Both carry the same FDA boxed warning about the toxin spreading beyond the injection site. Letybo's approval rested on three trials in about 1,270 people. Neither has a safety advantage established over the other.
Is either approved for the forehead?
No. In the US both are approved only for frown lines between the eyebrows.
Does Letybo contain human blood products?
Yes, it contains human serum albumin, as most brands do. Daxxify is the exception — it uses a lab-made peptide instead.