Letybo
A neurotoxin injection at the forehead. Several small injections are placed across the muscle rather than one large one in the middle.
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Dermapedia / CompareProcedures
Letybo vs Dysport
Both are botulinum toxin injections for the frown lines between the eyebrows. Letybo is the newer option in the US. Dysport has been sold here since 2009 and also treats some medical conditions. The two have never been tested against each other, and their unit counts do not convert between brands.
At a glance
| The difference | Letybo | Dysport |
|---|---|---|
| Cost | Sometimes offered at a lower price | Whatever the clinic charges |
Dysport
A neurotoxin injection between the brows. Only a small volume goes in at each point, and the effect builds over the following days rather than immediately.
Side by side
The differences that matter
What you actually do
Letybo
Several small shots, in clinic
A botulinum toxin type A that was widely used in Asia before it reached the US.
Dysport
Several small shots, in clinic
The same kind of toxin, on the US market since 2009 and in Europe for longer.
What you can expect to see
Letybo
Frown lines soften
Letybo beat a placebo in all three of its trials, which included about 1,270 people between them.
Dysport
Frown lines soften
Dysport beat a placebo too. Its label reports up to four months of effect.
More photographs
Dysport
Dysport's protein wrapper comes in a range of sizes, so the bundles are not all the same weight. The lighter molecules can travel farther in the skin. Remember, Dysport Diffuses!
Who should not have it
Letybo
Infection at the site, or a past reaction
A past reaction to any botulinum toxin counts.
Dysport
The same, plus a cow's milk allergy
The milk protein rule is specific to Dysport.
Cost
Letybo
Sometimes offered at a lower price
Being the newer arrival is part of the pitch. What you actually pay is set by the clinic.
Dysport
Whatever the clinic charges
People pick it for the longer US track record rather than the price.
Who tends to be happy with it
Letybo
- Best for — People offered it at a lower price.
- The mindset — You are comfortable with a newer arrival in the US.
Dysport
- Best for — People who want the longer US track record.
- The mindset — You would rather have the familiar option.
What "new" does and does not mean
Letybo
Letybo is new in the United States, not new in the world. It has been used in South Korea and other markets for years. Its US approval rested on three trials in more than 1,200 people.
The fine print
Letybo
Letybo is made by Hugel, a Korean company. It was approved in the US in 2024 and launched here in 2025. It holds no medical approvals in the US.
Both products are approved in the US for one cosmetic use: the glabellar (frown) lines between the eyebrows. Neither is approved here for forehead lines or crow's feet. Dysport's cosmetic approval is written for adults under 65.
Dysport
Dysport also holds two medical approvals: cervical dystonia, a condition that pulls the neck muscles out of position, and spasticity, a stiffening of muscles.
The labelled cosmetic dose for frown lines is 20 units of Letybo and 50 units of Dysport, each given as several small injections across the same area. Both labels state that their units cannot be converted into another brand's units, so the two figures are not comparable.
Common questions
Questions Patients Ask
Is Letybo as good as Dysport?
For frown lines, both work better than a placebo in their own trials, and most people would not be able to tell the results apart. The two have never been tested against each other, so nobody can rank them.
Why does Letybo use 20 units and Dysport 50?
Because a unit is not a fixed amount. Each brand measures potency with its own laboratory method, and both labels say their units cannot be converted into any other brand's. The unit count tells you nothing about strength.
Is Letybo cheaper?
It entered the US market positioned as a lower-cost option, but what you pay depends on the clinic. Ask for the price of the whole treatment rather than the price per unit — that is the only figure you can compare across brands.
Is Letybo safe?
It carries the same FDA boxed warning as every botulinum toxin product, about the toxin spreading beyond the injection site. Its approval was based on three trials in about 1,270 people. It has less long-term US use behind it than Dysport simply because it arrived later.
Can Letybo treat forehead lines?
Not on-label. In the US it is approved only for frown lines. The same is true of Dysport.
Which one works faster?
Neither label states a time to onset for these products, so there is no reliable published number to compare. In practice, botulinum toxin generally starts to show within a few days and settles over two weeks.