Juvelook
Lactic acid particles plus hyaluronic acid The particles are a close relative of the material in Sculptra. The hyaluronic acid is there to carry them and to hydrate.
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Juvelook vs Rejuran
Juvelook is better for skin that has gone soft, crepey or slightly hollow. It leaves tiny lactic acid particles in the skin that push your body to build its own collagen over the following months. Rejuran is better for rough texture, fine lines, shallow acne scars and skin that is thin or easily irritated. It uses polynucleotides, which are fragments of salmon DNA, to nudge the skin into repairing itself. Both are courses of two to three visits, and no trial has put them head to head.
At a glance
| The difference | Juvelook | Rejuran |
|---|---|---|
| What is in the syringe | Lactic acid particles plus hyaluronic acid | Polynucleotides from salmon DNA |
| What it feels like | Stings, then aches a little | Many small pinpricks |
| Downtime and side effects | Swelling, bruising, tenderness | Bumps, redness, bruising |
| Cost | Priced per session, sold as a course | Priced per session, and you need three |
Rejuran
Side by side
The differences that matter
What is in the syringe
Juvelook
Lactic acid particles plus hyaluronic acid
The particles are a close relative of the material in Sculptra. The hyaluronic acid is there to carry them and to hydrate.
Rejuran
Polynucleotides from salmon DNA
Purified DNA fragments. They are not a filler and they do not add volume.
What it improves
Juvelook
Firmness and thickness
Softening jawline, crepey cheeks, large pores, and skin that has thinned. It can gently restore mild volume loss.
Rejuran
Skin quality
Fine lines, rough texture, shallow acne scars, dullness, and skin that reacts to everything.
How soon you see something
Juvelook
A little now, the real change at month three
The hyaluronic acid gives a short-lived plumping in the first week. The collagen change builds over two to three months.
Rejuran
Two to four weeks, building for three months
Nothing changes on the day. Skin usually feels smoother and calmer first, and looks smoother later.
How many sessions
Juvelook
Two to three, a month apart
It is a course, not a single appointment.
Rejuran
Three, three to four weeks apart
Most people then repeat one session every six to twelve months.
How long it lasts
Juvelook
Around a year, sometimes longer
Collagen made in response to the treatment fades slowly.
Rejuran
Around six to twelve months
It is usually described as maintenance rather than a one-off fix.
What it feels like
Juvelook
Stings, then aches a little
Numbing cream first. Some tenderness and swelling for a day or two.
Rejuran
Many small pinpricks
Small raised bumps sit at each injection point afterwards. They flatten in one to two days.
What it will not do
Juvelook
It will not fix a wrinkle from movement
A frown line caused by muscle needs botulinum toxin, not a collagen stimulator.
Rejuran
It will not lift or add volume
Rejuran works on the quality of the skin. A hollow cheek stays hollow.
Downtime and side effects
Juvelook
Swelling, bruising, tenderness
Small lumps under the skin are the uncommon risk, as with any collagen stimulator. Even spread and massage reduce it.
Rejuran
Bumps, redness, bruising
Usually gone in 48 hours. Most people plan it a few days before anything social.
Cost
Juvelook
Priced per session, sold as a course
Ask for the price of the whole plan rather than one visit.
Rejuran
Priced per session, and you need three
Maintenance later is usually one session at a time.
The at-home or drugstore version
Juvelook
There is no home version
The particles have to sit in the layer where collagen is made, a few millimetres down. Nothing you rub on gets there.
Rejuran
Salmon DNA serums are a different thing
PDRN creams and ampoules exist and are pleasant on the skin. Injected polynucleotides are placed inside the skin. A serum sits on top of it.
Who each suits
Juvelook
- Best for — Skin that has lost firmness, plus mild volume loss.
- The mindset — You will wait three months for a result you cannot point at.
Rejuran
- Best for — Texture, fine lines, shallow scarring, sensitive or fragile skin.
- The mindset — You want better skin, not a different face.
They promise similar things by different routes
Juvelook
Juvelook works by irritating the skin on purpose. The tiny particles are treated as something to wall off, and the repair response lays down new collagen. That takes months, which is why nothing looks different at first.
Rejuran
Rejuran works by supplying material the skin uses to repair. Polynucleotides sit in the skin and appear to support healing and hydration rather than force a building response.
Before you book
More photographs
Rejuran
Rejuran is injected in small amounts across the area. It is usually done as a series of visits.
Common questions
Questions Patients Ask
Can you have Juvelook and Rejuran together?
Many clinics do offer both, usually at separate appointments rather than on the same day. There is no evidence that combining them works better than either one alone, so treat it as a preference, not a proven plan.
Which one is better for acne scars?
Rejuran is the one usually chosen for shallow, soft acne scarring and rough texture. Deep, tethered box scars need something that breaks the tether underneath, such as subcision or a resurfacing laser.
Is Rejuran a filler?
No. It does not add volume and it will not lift a hollow. It is injected into the skin to change how the skin itself looks and behaves.
Is Juvelook the same as Sculptra?
They are close relatives, not the same product. Both use a lactic acid material to stimulate collagen. Juvelook uses smaller particles placed in the skin for texture and firmness, while Sculptra is placed deeper for broad volume loss.
How much do they hurt?
Both sting. Numbing cream is standard for either. Rejuran feels like many small pinpricks and leaves visible bumps for a day or two, which most people find is the harder part to plan around.
Are these available in the United States?
Neither product is approved in the US for these uses, though some clinics offer them. In Korea and much of Asia and Europe they are routine, which is why most of what you read online comes from there.