Evolysse
Two products: Smooth and Form Both are hyaluronic acid gels. A provider injects them into and under the skin. Names such as Evolysse Lips and Evolysse Sculpt turn up in trade press. They have no FDA record and are not sold here.
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Dermapedia / CompareProcedures
Evolysse vs Juvederm
Evolysse is approved for one thing: the folds that run from your nose to your mouth. It has two products, and published follow-up that stops at 12 months. Juvederm is the choice for anywhere else on the face. Its seven products have been approved area by area since 2006, and no trial has ever compared the two.
At a glance
| The difference | Evolysse | Juvederm |
|---|---|---|
| What is in it | Hyaluronic acid gel with lidocaine | A range of gels, soft to firm |
| What is still unknown | Anything past the first year | How every filler behaves long term |
Juvederm
Side by side
The differences that matter
What you actually get
Evolysse
Two products: Smooth and Form
Both are hyaluronic acid gels. A provider injects them into and under the skin. Names such as Evolysse Lips and Evolysse Sculpt turn up in trade press. They have no FDA record and are not sold here.
Juvederm
Seven products, aimed at different areas
Ultra XC, Ultra Plus XC, Voluma XC, Vollure XC, Volbella XC, Volux XC and Skinvive. Each area belongs to a named product, not to the brand.
What is in it
Evolysse
Hyaluronic acid gel with lidocaine
Smooth and Form use slightly different gel strengths. Both add lidocaine, a numbing drug. Both are crosslinked with BDDE, the same crosslinker used across the category.
Juvederm
A range of gels, soft to firm
Volbella XC is the lightest and Volux XC the firmest. The XC versions add lidocaine too.
What the trial actually showed
Evolysse
Tested against Restylane-L, not Juvederm
One blinded study in 140 people compared the two gels, one on each side of the face. It was built only to rule out a difference bigger than half a grade. That is not a finding that either product is better, and it is not a proven tie.
Juvederm
A separate trial for each product
Most did not name their comparator. Volbella XC's lip trial ran against Restylane-L.
How far the published follow-up runs
Evolysse
12 months
Plus 3 months after an optional repeat treatment. Photo reviewers found 65% of Smooth and 72% of Form subjects improved a grade at 12 months. At 6 months the same review gave 52% and 45%. That dip points to noise in the measuring, not a filler that improved with time.
Juvederm
6 months to 24 months, by product
It varies by product. Voluma XC ran 24 months, at the long end. Skinvive ran 6 months, at the short end.
What is still unknown
Evolysse
Anything past the first year
There is no independent published research on Evolysse, and no record of how it behaves once on sale. It has only been sold in the US since early 2025. Nothing covers any area outside the nasolabial fold.
Juvederm
How every filler behaves long term
Small MRI series have found hyaluronic acid still detectable years after injection. That is the material still being there, not a continued cosmetic effect. The series are small and selected.
The at-home or drugstore version
Evolysse
There is no home version
Evolysse is a gel placed under the skin with a needle. Nothing sold over the counter does that.
Juvederm
There is no home version
Lip plumpers mildly irritate the lip so it swells for a few hours. That is not the same as placing a gel under it.
Who tends to be happy with it
Evolysse
- Best for — Someone treating the fold from nose to mouth, who is fine with one trial and 12 months of follow-up.
- The mindset — New, approved through the strict route, short on outside evidence.
Juvederm
- Best for — Anyone treating an area outside that fold, where Evolysse has no approval at all.
- The mindset — Twenty years of record, product by product. Every duration figure is still just a study window.
Why two numbers from the same trial disagree
Evolysse
The Evolysse trial reported the same people two ways. Reviewers scoring photographs found 45 to 52% improved at 6 months. Evaluators who looked at the same people on the same day, using a different scale, found 95 to 98%.
The fine print
Evolysse
Evolysse is approved for one thing. The wording covers "dermal and subdermal injection to correct moderate to severe dynamic facial wrinkles and folds (such as NLFs) in adults 22 years or older". Smooth and Form share that single indication. There is no lip, cheek, chin, jawline, temple or under-eye approval. Use anywhere else is off-label — legal and common, but with no trial behind it.
The word "dynamic" in the Evolysse wording is regulatory text, not marketing. Most US filler approvals just say "facial wrinkles and folds". It does not show that Evolysse works better in areas that move, because that comparison has not been made.
Juvederm
Juvederm has separate approved uses across about a dozen areas of the face and neck, from folds and lips to cheeks, chin, temples, jawline and the under-eye hollow. Each belongs to a named product, not to the brand.
More photographs
Juvederm
Compare the total cost
Evolysse
Ask which Evolysse filler, treatment area and number of syringes the quote includes.
Juvederm
Ask which Juvederm filler and how many syringes would be used for the same goal. Include the follow-up and touch-up policy.
Common questions
Questions Patients Ask
Is Evolysse FDA-approved?
Yes. Evolysse Smooth and Evolysse Form were approved on 13 February 2025 through premarket approval, the strict route required for dermal fillers. The approval holder is Symatese and Evolus is the US commercial partner. Only those two products are approved; names such as Evolysse Lips and Evolysse Sculpt have no FDA record.
What is Evolysse approved to treat?
One thing: moderate to severe dynamic facial wrinkles and folds, such as nasolabial folds, in adults 22 years or older, by dermal and subdermal injection. It has no approval for lips, cheeks, chin, jawline, temples or the under-eye area.
How does Evolysse compare with Juvederm in a trial?
It has not been compared with Juvederm at all. The Evolysse trial used Restylane-L as its comparator, in a split-face double-blind study of 140 people, and it was a non-inferiority design. Comparing an Evolysse figure with a Juvederm figure from a different trial is not a valid comparison.
How long does Evolysse last?
Its published follow-up runs to 12 months, plus 3 months after optional repeat treatment. At 12 months, independent photo review found 64.6% of Evolysse Smooth and 72.1% of Evolysse Form subjects met a one-grade improvement. Nothing is known past that point, because that is where the trial stopped.
Is Evolysse safe if it is so new?
It went through the same FDA approval route as Juvederm, with a controlled trial required before sale. What it does not yet have is the years of post-market reporting and independent case series that reveal rare or delayed problems. That is a gap in what is known rather than a known problem.
What is Cold-X?
It is the manufacturer's name for a low-temperature manufacturing process. Like Vycross for Juvederm and CPM for Belotero, the name does not appear anywhere in the FDA record, which describes Evolysse in generic terms as BDDE-crosslinked hyaluronic acid.
What is the difference between Evolysse Smooth and Evolysse Form?
Hyaluronic acid concentration: Smooth is 20 mg/mL and Form is 22 mg/mL. Both contain 3 mg/mL lidocaine and both carry the same single approved indication. In the trial they were tested as separate arms and both met non-inferiority against the comparator.
Can Evolysse be dissolved?
Yes, it is hyaluronic acid, so hyaluronidase breaks it down. That use of the enzyme is off-label in the US. No published laboratory work has compared how much enzyme Evolysse needs against how much Juvederm needs.
Safety to keep in mind
Evolysse was held to the same standard as Juvederm. It went through the FDA's strictest device route, which required a controlled clinical trial before the gel could be sold. In that sense it is not an unknown quantity.
What it lacks is time. Some filler problems are rare or slow, such as inflammatory lumps that show up months after injection. Those surface in reports gathered after a product goes on sale, not in a 12-month trial. For Evolysse, that record does not exist yet. That says how much is known, not that there is a problem.
For a nasolabial fold, both are approved and neither has been tested against the other. The difference is in published follow-up: 12 months for Evolysse, against 18 months for Vollure XC.
Approvals, dates and wording. Useful for checking a claim, but it changes very little about what you do next.
Ingredients and makers. Evolysse Smooth is hyaluronic acid at 20 mg/mL and Form at 22 mg/mL, each with 3 mg/mL lidocaine. Juvederm runs 15 mg/mL (Volbella XC) to 25 mg/mL (Volux XC), with 0.3% lidocaine in the XC versions. The Evolysse approval holder is Symatese, with Evolus as US commercial partner; Juvederm is Allergan's. The trade names Cold-X, Hylacross and Vycross do not appear in the FDA record.
Approval dates and pathway. Both brands came through premarket approval (PMA). FDA approved Evolysse Smooth and Evolysse Form on 13 February 2025. Juvederm's first approval dates from 2 June 2006 for the Ultra line and 2013 for the Voluma line; every later Juvederm product was added as a supplement to one of those two PMAs, each with its own review and date.